
The San Francisco safehouses were closed in 1965, and the New York City safehouse soon followed in 1966.

The safehouses were dramatically scaled back in 1963, following a report by CIA Inspector General John Earman which strongly recommended closing the facility.

Operation Midnight Climax started in 1954 consisted of a web of CIA-run safehouses in San Francisco at 225c Chestnut Street, San Francisco, CA, and Mill Valley, California, as well as New York City. "No one knows where they are now, or what effects they may have suffered." Background History George Hunter White, an agent at the Federal Bureau of Narcotics, and Ira "Ike" Feldman, a former military intelligence officer, who oversaw San Francisco experiments, noticed that subjects spoke far more freely when under the influence of a combination of drugs and sex. Official results of these experiments were not released, but accounts from supervisors of the experiments give little insight to the findings. Hundreds of federal agents, field operatives, and scientists worked on these programs before they were shut down in the 1960s. Unlike Project Artichoke, Operation Midnight Climax gave Gottlieb permission to test drugs on unknowing citizens, which made way for the legacy of this operation. Gottlieb based his plan for Project MKUltra and Operation Midnight Climax off of interrogation method research under Project Artichoke. Under the Cold War and fears of the Soviet Union and China, Gottlieb felt inspired to investigate methods of mind control. Sidney Gottlieb was a chemist who was chief of the Chemical Division of the Technical Services Staff of the CIA.

It was initially established in 1954 by Sidney Gottlieb and placed under the direction of the Federal Bureau of Narcotics in Boston, Massachusetts with the "Federal Narcotics Agent and CIA consultant" George Hunter White under the pseudonym of Morgan Hall. Operation Midnight Climax was an operation carried out by the CIA as a sub-project of Project MKUltra, the mind-control research program that began in the 1950s. CIA sub-project of Project MKUltra studying the effects of LSD
